| Autor: |
Jakobsen, P H, Hviid, L, Theander, T G, Afare, E A, Ridley, R G, Heegaard, P M, Stuber, D, Dalsgaard, K, Nkrumah, F K |
| Zdroj: |
Infection and Immunity; January 1993, Vol. 61 Issue: 1 p268-273, 6p |
| Abstrakt: |
The merozoite proteins merozoite surface protein 1 (MSP-1) and rhoptry-associated protein 1 (RAP-1) and synthetic peptides containing sequences of MSP-1, RAP-1, and erythrocyte-binding antigen 1, induced in vitro proliferative responses of lymphocytes collected from Ghanaian blood donors living in an area with a high rate of transmission of malaria. Lymphocytes from a large proportion of the Ghanaian blood donors proliferated in response to the RAP-1 peptide, unlike those of Danish control blood donors, indicating that this sequence contains a malaria-specific T-cell epitope broadly recognized by individuals living in an area with a high transmission rate of malaria. Most of the donor plasma samples tested contained immunoglobulin G (IgG) and IgM antibodies recognizing the merozoite proteins, while only a minority showed high IgG reactivity to the synthetic peptides. |
| Databáze: |
Supplemental Index |
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