Amino Acid Flux and Protein Synthesis After Exposure of Rats to Either Diplococcus pneumoniaeor Salmonella typhimurium

Autor: Wannemacher, Robert W., Powanda, Michael C., Dinterman, Richard E.
Zdroj: Infection and Immunity; July 1974, Vol. 10 Issue: 1 p60-65, 6p
Abstrakt: At 26 h after inoculation of rats with Diplococcus pneumoniae, the serum concentrations of 10 and 20 individual amino acids were lower than corresponding values observed in pair-fed controls. In contrast, only 2 of 20 serum amino acids were similarly decreased in rats inoculated with Salmonella typhimurium.Despite these serum differences, a greater accumulation of labeled non-metabolizable amino acids occurred in the livers of rats infected with S. typhimurium.These data suggested a greater increase in the flux of amino acids from muscle to liver in the rats infected with S. typhimuriumas compared to those infected with D. pneumoniae.A similar increase in serum protein synthesis was observed in rats infected with D. pneumoniaeor S. typhimurium.However, with the latter infection, a larger percentage of the amino acids appeared to be utilized as a source of energy in addition to their role as precursors of proteins.
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