| Autor: |
Koszinowski, U H, Keil, G M, Schwarz, H, Schickedanz, J, Reddehase, M J |
| Zdroj: |
The Journal of Experimental Medicine; July 1987, Vol. 166 Issue: 1 p289-294, 6p |
| Abstrakt: |
We have constructed target cells by cotransfection of the MHC gene Ld and fragments of murine cytomegalovirus (MCMV) DNA coding for nonstructural immediate-early (IE) proteins. Transfectants were tested by using CTL clone IE1 with specificity for an IE epitope presented in association with Ld. Data show that clone IE1 recognizes a product of the ie1 transcription unit of MCMV, and that its specificity is shared by approximately 25% of polyclonal IE-specific CTL. The results provide the first definite evidence that expression of a herpes virus IE gene encoding a regulatory protein gives rise to antigen expression detectable by specific CTL. |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
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