Plasmid-mediated tetracycline resistance in Haemophilus ducreyi

Autor: Albritton, W L, Maclean, I W, Slaney, L A, Ronald, A R, Deneer, H G
Zdroj: Antimicrobial Agents and Chemotherapy; February 1984, Vol. 25 Issue: 2 p187-190, 4p
Abstrakt: Clinical isolates of Haemophilus ducreyi were shown to be resistant to tetracycline. Resistance was associated in some strains with a 30-megadalton plasmid capable of transferring resistance in conjugative matings with other strains of H. ducreyi and other species of Haemophilus. Restriction endonuclease digestion patterns suggest a relationship between H. ducreyi plasmids and other tetracycline resistance plasmids in Haemophilus. The presence of plasmid-mediated resistance to the tetracyclines limits the use of these agents for the treatment of chancroid.
Databáze: Supplemental Index