Eco-efficient one-pot tandem synthesis of 1-aryl-1H-tetrazol-5-amine by CAN via in situgenerated 1-phenylthiourea and heterocumulene

Autor:	Kondhare, Dasharath D., Bhadke, Venkat V., Deshmukh, Sushma S., Wakhradkar, Mahesh G., Totawar, Balaji B.
Zdroj:	Journal of the Indian Chemical Society; August 2021, Vol. 98 Issue: 8
Abstrakt:	A simple, cost-effective, environmentally benign, and efficient one-pot tandem approach to the synthesis of pharmaceutically important 1-aryl-1H-tetrazole-5-amines 3a-k and 4a-k has been described. The reaction utilized 1-phenyl thiourea, which was generated in situ from aqueous ammonia and isocyanates 1a-k, for the formation of heterocumenes using sodium azide, triethylamine, and ceric ammonium nitrate (CAN) to obtain various aryl-substituted 1H-tetrazole-5-amines (3a-k) in good to excellent yields.
Databáze:	Supplemental Index
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