| Autor: |
Elwell, Lynn P., Roberts, Marilyn, Mayer, Leonard W., Falkow, Stanley |
| Zdroj: |
Antimicrobial Agents and Chemotherapy; March 1977, Vol. 11 Issue: 3 p528-533, 6p |
| Abstrakt: |
Several β-lactamase-producing, penicillin-resistant strains of Neisseria gonorrhoeaewere examined for R plasmids. Penicillin-resistant strains isolated from men returning from the Far East and their contacts contained a 4.4 × 106-dalton plasmid in common. Transformation studies and the isolation of a spontaneous penicillin-susceptible segregant showed that the structural gene for β-lactamase was part of the 4.4 × 106-dalton plasmid. An additional penicillin-resistant gonococcal strain isolated in London was found to harbor a 3.2 × 106-dalton R plasmid. Deoxyribonucleic acid (DNA)-DNA duplex studies revealed that the penicillin-resistant gonococcal isolates contained a significant portion (about 40%) of the transposable DNA sequence, TnA, which includes the β-lactamase gene commonly found on R plasmids of the Enterobacteriaceaeand Haemophilus influenzae. |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
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