Cutaneous and systemic anti-allergic potential of xylopic acid in rodents

Autor: Osafo, Newman, Antwi, Aaron Opoku, Mante, Priscilla Kolibea, Osei, Yaa Asantewaa, Yeboah, Oduro Kofi, Otu-Boakye, Sarah
Zdroj: Advances in Traditional Medicine; 20210101, Issue: Preprints p1-10, 10p
Abstrakt: Xylopic acid is a kaurene diterpene isolated from the dried fruit of Xylopia aethiopica. It has been identified to exhibit analgesic activity and also demonstrates acute and chronic anti-inflammatory activity. This study aimed at investigating its potential anti-allergic activity using rodent models. To investigate this, antihistaminic study using guinea pig ileum preparation and clonidine-induced catalepsy model were employed. Also, cutaneous anaphylaxis was investigated using pinnal inflammation and compound 48/80-induced cutaneous anaphylaxis models. Systemic anaphylaxis was studied using compound 48/80 systemic anaphylaxis and lipopolysaccharide (LPS)-induced septic shock models. XA exerted H1antagonism in the ex vivo study using guinea pig ileum which supported its anti-histaminic activity in the clonidine-induced catalepsy. It also suppressed pinnal inflammation and inhibited mast cell degranulation and tissue damage significantly (P< 0.0001). In the systemic anaphylactic study, XA offered up to 90% survival rate in the compound 48/80-challenged mice and up to 70% protection against LPS-induced endotoxic shock at the studied doses. Xylopic acid showed histamine H1receptor antagonism and subsequently inhibited clonidine-induced catalepsy. It inhibited passive cutaneous anaphylaxis, compound 48/80-induced anaphylaxis and the LPS-induced septic shock. These corroborate the cutaneous and systemic anti-allergic potential of XA in rodent allergy models.
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