| Autor: |
Tegla, Cosmin A, Herrera, Alberto M, Seffens, Angelina M, Fanok, Melania H, Dean, George, Kawaoka, John, Laird, Mary E, Fulmer, Yi, Willerslev-Olsen, Andreas, Hymes, Kenneth B., Latkowski, Jo-Ann, Odum, Niels, Feske, Stefan, Shopsin, Bo, Torres, Victor, Kadin, Marshall E., Geskin, Larisa J, Koralov, Sergei B. |
| Zdroj: |
Blood; November 2019, Vol. 134 Issue: 1, Number 1 Supplement 1 p659-659, 1p |
| Abstrakt: |
It has been proposed that bacteria play a direct role in progression of cutaneous T cell lymphoma (CTCL), although definitive evidence is missing, and the underlying mechanism of how microbes contribute to disease progression remains unknown. The skin of CTCL patients is frequently colonized with Staphylococcus aureus (S. aureus)strains and infections with hospital and community associated strains of S. aureusare a frequent cause of morbidity and mortality among patients with advanced CTCL. Here we provide a comprehensive analysis of the association between CTCL and S. aureuscolonization, and use our unique pre-clinical animal model of CTCL to determine the cause-effect relationship between skin-associated S. aureusand CTCL progression. |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
|
