| Autor: |
Menezes, Joelma F, Carvalho, Magda SO, Rocha, Larissa C, Nascimento, Valma Maria Lopes, Lyra, Isa Menezes, Carvalho, Mauricio, Salvino, Marco Aurelio, Cerqueira, Bruno, Villas Boas, Wendell, Goncalves, Marilda Souza |
| Zdroj: |
Blood; November 2014, Vol. 124 Issue: 21 p4921-4921, 1p |
| Abstrakt: |
Background: Sickle cell disease (SCD) has a clinical heterogeneity and vasoocclusive events are an important clinical characteristic among patients. The paraoxonase 1 (PON 1) is a serum glycoprotein associated with the high-density lipoproteins cholesterol (HDL-C) and the variability of the PON1 activity has been associated with the PON1genotypes. We tested a possible relevance of the PON1 in SCD patients in steady and crisis state, studying its activity and genotype, investigating M55L (rs854560) and R192Q (rs662) polymorphisms, and their association with markers of hemolysis, inflammation and organ dysfunction. |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
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