Updated and revised normal values of aortic pulse wave velocity in children and adolescents aged 3–18 years

Autor: Hidvégi, Erzsébet Valéria, Jakab, Andrea Emese, Lenkey, Zsófia, Bereczki, Csaba, Cziráki, Attila, Illyés, Miklós
Zdroj: Journal of Human Hypertension; July 2021, Vol. 35 Issue: 7 p604-612, 9p
Abstrakt: Measurement of aortic pulse wave velocity (PWVao) is recommended for stratifying individual cardiovascular (CV) risk in adults. Diseases in children and adolescents might influence aortic stiffness. It is necessary to exclude overweight (OW), obese (O) subjects, and individuals with increased systolic (SBP) and/or diastolic blood pressure (DBP) from the population, when creating normal values of PWVaoin children and adolescents. Body mass index (BMI), SBP/DBP cut-off values have remarkably changed in this population during the last decade. Aims of our study were to expand our previously published PWVaodatabase and to revise it by using the recently determined normal values. PWVaowas measured by an occlusive-oscillometric device (Arteriograph, TensioMed Ltd, Budapest, Hungary) in a healthy population aged 3–18 years. 7940 (4374 boys) participants were recruited, 1912 OW/O subjects and 1368 individuals with high SBP/DBP were excluded. Finally, n= 4690 (2599 boys) participants were enrolled. Mean PWVaovalues increased from 5.4 ± 0.6 to 6.4 ± 0.5 m/s (p< 0.05) in boys and from 5.5 ± 0.6 to 6.4 ± 0.5 m/s (p< 0.05) in girls. Mean PWVaovalues were significantly lower in our new study, in boys in age groups of 9–16, in girls in age groups of 11–17. This is the largest and widest age-ranged database of PWVaopublished to date. Due to the change of BMI and SBP/DBP reference values during the last decade, the “old” database of PWVaoneeded to be revised. As a result of this, normal values of PWVaodecreased significantly in both sexes.
Databáze: Supplemental Index