| Autor: |
Abdirama, Dimas, Tesch, Sebastian, Grießbach, Anna-Sophie, von Spee-Mayer, Caroline, Humrich, Jens Y., Stervbo, Ulrik, Babel, Nina, Meisel, Christian, Alexander, Tobias, Biesen, Robert, Bacher, Petra, Scheffold, Alexander, Eckardt, Kai-Uwe, Hiepe, Falk, Radbruch, Andreas, Burmester, Gerd-Rüdiger, Riemekasten, Gabriela, Enghard, Philipp |
| Zdroj: |
Kidney International; January 2021, Vol. 99 Issue: 1 p238-246, 9p |
| Abstrakt: |
Systemic lupus erythematosus is a systemic and chronic autoimmune disease characterized by loss of tolerance towards nuclear antigens with autoreactive CD4+T cells implicated in disease pathogenesis. However, very little is known about their receptor specificity since the detection of human autoantigen specific CD4+T cells has been extremely challenging. Here we present an analysis of CD4+T cells reactive to nuclear antigens using two complementary methods: T cell libraries and antigen-reactive T cell enrichment. The frequencies of nuclear antigen specific CD4+T cells correlated with disease severity. These autoreactive T cells produce effector cytokines such as interferon-γ, interleukin-17, and interleukin-10. Compared to blood, these cells were enriched in the urine of patients with active lupus nephritis, suggesting an infiltration of the inflamed kidneys. Thus, these previously unrecognized characteristics support a role for nuclear antigen-specific CD4+T cells in systemic lupus erythematosus. |
| Databáze: |
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