| Autor: |
Mortimer, Edward A., Kimura, Mikio, Cherry, James D., Kuno-Sakai, Harumi, Stout, Mason G., Dekker, Cornelia L., Hayashi, Rika, Miyamoto, Yoshio, Scott, Jane V., Aoyama, Tatsuo, Isomura, Shin, Iwata, Takashi, Kamiya, Hitoshi, Kato, Tatsuo, Noya, Junko, Suzuki, Eitaro, Takeuchi, Yoshinao, Yamaoka, Hideki |
| Zdroj: |
American Journal of Diseases of Children; August 1990, Vol. 144 Issue: 8 p899-904, 6p |
| Abstrakt: |
• The clinical efficacy of an acellular pertussis vaccine containing lymphocytosis-promoting factor, filamentous hemagglutinin, agglutinogens, and the 69-kd outer membrane protein, combined with diphtheria and tetanus toxoids and adsorbed onto an aluminum salt, was assessed in a household contact study. The occurrence of pertussis 7 to 30 days following home exposure among 62 previously vaccinated children was compared with that among 62 unvaccinated children similarly exposed. Classic whooping cough was diagnosed in 43 unimmunized children, and 1 vaccinated child experienced a 5-week illness that was probably pertussis (efficacy, 98%; 95% confidence interval, 84% to 99%). A few children in each group incurred respiratory illnesses that may have represented mild, atypical pertussis; including these as probable pertussis, vaccine efficacy was 81% (95% confidence interval, 64% to 90%). It is concluded that prior immunization with this four-component pertussis vaccine combined with diphtheria and tetanus toxoids is highly efficacious in preventing pertussis.(AJDC. 1990;144:899-904) |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
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