| Autor: |
do Monte, Felipe Alves, Sung Park, Min, Gokani, Vishal, Singhal, Mohit, Ma, Chi, Aruwajoye, Olumide O., Niese, Brad, Liu, Xiaohua, Kim, Harry K.W. |
| Zdroj: |
Revue de Chirurgie Orthopédique et Traumatologique; June 2020, Vol. 106 Issue: 4 p398-398, 1p |
| Abstrakt: |
Legg–Calvé–Perthes disease is a juvenile ischemic osteonecrosis which produces extensive necrotic cell debris and release of damage associated molecular patterns (DAMPs) in the femoral head. The necrotic bone environment induces a chronic inflammatory repair response with excessive bone resorption leading to deformity and early osteoarthritis. Currently, there is no minimally invasive method to clear the necrotic materials from the bone to decrease the inflammatory burden of the necrotic environment and to improve the healing process. |
| Databáze: |
Supplemental Index |
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