| Autor: |
Karadzov Orlic, Natasa, Egic, Amira, Damnjanovic‐Pazin, Barbara, Lukic, Relja, Joksic, Ivana, Mikovic, Zeljko |
| Zdroj: |
Congenital Heart Disease; November 2019, Vol. 14 Issue: 6 p1094-1101, 8p |
| Abstrakt: |
The objective of this study was to analyze if the addition of simple cardiac scan in cases with increased nuchal translucency (NT) and/or abnormal ductus venosus (DV) blood flow, and/or tricuspid regurgitation (TCR) can improve detection of congenital heart defects (CHD) in chromosomally normal fetuses without non‐cardiac defects at 11‐13 + 6 gestational weeks in a population of singleton pregnancies. During the 10 years period, all singleton pregnancies at 11‐13 + 6 weeks were routinely scanned for NT, DV blood flow and TCR assessment and, if a single of these parameters was abnormal, simple cardiac scan with 2D gray scale and color and/or directional power Doppler in 4‐chamber (4‐CV) and 3 vessel and trachea views (3VTV) was performed. The sensitivity and specificity of NT ≥ 95th + DV R/A a‐wave + TCR in detecting CHD were 77% and 97%, respectively, and of simple cardiac scan, 67% and 98%, respectively. Area under the curve of receiver operating characteristic curve of NT ≥ 95th + DV R/A a‐wave + TCR was 0.838, and of NT ≥ 95th + DV R/A a‐wave + TCR + simple cardiac scan was 0.915. In chromosomally normal fetuses without non‐cardiac anomalies, addition of simple cardiac scan to the combined first trimester screening parameters improves detection of major CHD during first trimester. |
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