Volatility Estimates Increase Choice Switching and Relate to Prefrontal Activity in Schizophrenia

Autor: Deserno, Lorenz, Boehme, Rebecca, Mathys, Christoph, Katthagen, Teresa, Kaminski, Jakob, Stephan, Klaas Enno, Heinz, Andreas, Schlagenhauf, Florian
Zdroj: Biological Psychiatry: Cognitive Neuroscience and Neuroimaging; February 2020, Vol. 5 Issue: 2 p173-183, 11p
Abstrakt: Reward-based decision making is impaired in patients with schizophrenia (PSZ), as reflected by increased choice switching. The underlying cognitive and motivational processes as well as associated neural signatures remain unknown. Reinforcement learning and hierarchical Bayesian learning account for choice switching in different ways. We hypothesized that enhanced choice switching, as seen in PSZ during reward-based decision making, relates to higher-order beliefs about environmental volatility, and we examined the associated neural activity.
Databáze: Supplemental Index