| Autor: |
Brilhante, Raimunda SN, Pereira, Vandbergue S, Oliveira, Jonathas S, Rodrigues, Anderson M, de Camargo, Zoilo P, Pereira-Neto, Waldemiro A, Nascimento, Nilberto RF, Castelo-Branco, Débora SCM, Cordeiro, Rossana A, Sidrim, José JC, Rocha, Marcos FG |
| Zdroj: |
Future Microbiology; September 2019, Vol. 14 Issue: 14 p1221-1233, 13p |
| Abstrakt: |
Aim:This study investigated the effect of terpinen-4-ol against Sporothrix schenckiicomplex and its interactions with antifungals. Materials & methods:The antifungal activity of terpinen-4-ol was evaluated by broth microdilution. The potential effect on cellular ergosterol concentration was evaluated by spectrophotometry. The antibiofilm activity was evaluated by violet crystal staining and XTT reduction assay. The potential pharmacological interactions with antifungals were evaluated by the checkerboard assay. Results:terpinen-4-ol (T-OH) showed minimal inhibitory concentrations ranging from 4 to 32 mg/l decreasing cellular ergosterol content and presented a SMIC ranging from 64 to 1024 mg/l for Sporothrixspp. The combinations of T-OH with itraconazole or terbinafine were synergistic. Conclusion:T-OH has antifungal activity against Sporothrixspp. and acts synergistically with standard antifungals. |
| Databáze: |
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