| Autor: |
Bello, Adebayo J., Adams, Luqman A., Onyejepu, Nneka N., Igbinehi, Justice I., Igbari, Omoboyede F., Okpuzor, Joy |
| Zdroj: |
International Journal of Nano and Biomaterials; 2019, Vol. 8 Issue: 2 p129-145, 17p |
| Abstrakt: |
Nanosilver was synthesised by bioreduction using aqueous extracts of Moringa oleifera(MO-AgNPs) leaf and Allium cepabulb (AC-AgNPs) as reducing and capping agents. The nanosilver was characterised with UV/vis, FT-IR, and SEM-EDX. Microbiological activity on five Mycobacteriastrains: ATCC 35882, ATCC 25177, Mycobacteriumother than tuberculosis (MOTT), Mycobacterium fortuitumand multi drug resistance M. tuberculosis(MDR-MTB) was investigated using nitrate reductase assay (NRA). Results obtained for UV/vis gave absorption maxima at 430 nm for MO-AgNPs and 440 nm for AC-AgNPs. FT-IR showed functional groups associated with the biomolecular capping agents. SEM showed the nanosilver formed aggregates spherical and/or in oval shape with smooth surface. EDX spectra exhibited the presence of elemental silver. Minimum inhibitory concentration (MIC) study for both nanosilver against Mycobacteriaindicated a higher inhibitory activity for MO-AgNPs over the AC-AgNPs. Herein, we have reported the first biosynthesised nanosilver activity against Mycobacteriausing NRA. Nanosilver may therefore be developed as nanoaerosol for targeted and effective treatment of Mycobacteriainfections. |
| Databáze: |
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