| Autor: |
Deawati, Yusi, Onggo, Djulia, Mulyani, Irma, Hastiawan, Iwan, Utami, Ratna Annisa, Kurnia, Dikdik |
| Zdroj: |
Key Engineering Materials; July 2019, Vol. 811 Issue: 1 p22-27, 6p |
| Abstrakt: |
Superoxide dismutase (SOD) is an Mn-containing enzyme that catalyzes the conversion of superoxide (O2•−) into O2 and H2O2. To develop a small, non-protein Mn-containing SOD mimic, an [Mn(salen)Cl] complex was synthesized from MnCl2.4H2O and H2salen. The product yielded 75-90% reddish dark brown crystals indicative of the presence of manganese(III) metal ions. An elemental analysis showed that the compound contained: C = 48.36%; H = 4.34%; and N = 7.13%. Infrared spectra of this compound showed peaks at: υ(OH)=3426 (medium), υ(C=N)=1634 (very high), υ(CO)=1292 (high). An ESI-MS analysis (m/z) showed the presence of ionic species from the complex including (salen)(H+) = 269.0 and [Mn(salen)]+ = 320.9. Conductivity measurements revealed that the compound is neutral with a molar conductivity of 0.17 mS. Its magnetic moment of 5.2 BM was obtained from a magnetic susceptibility balance measurement, showing that the compound is paramagnetic. The SOD activity of this compound was given by IC50 = 2.5 ± 0.3 µM in a non-enzymatic riboflavin photoreduction in vitro test. |
| Databáze: |
Supplemental Index |
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