| Autor: |
Salazar-Gómez, Anuar, Sánchez-Chávez, Anahí C., Zepeda-Vallejo, Gerardo, Chamorro-Cevallos, Germán, Garduño-Siciliano, Leticia, Vargas-Díaz, Elena |
| Zdroj: |
Natural Product Communications; July 2019, Vol. 14 Issue: 7 |
| Abstrakt: |
The aim of the present study was to evaluate the hypolipidemic effect of Trixis angustifoliaaqueous extract (TxAE) on Triton WR-1339- and high-fat diet-induced hyperlipidemic mice. In the Triton model, treatment with TxAE at 100 and 200 mg/kg body weight produced a significant decrease in triglycerides and very low-density lipoprotein levels and a significant increase in high-density lipoprotein (HDL). Similarly, administration of TxAE along with the high-fat diet induced a significant decrease in serum total cholesterol, low-density lipoproteins, and increase in HDL. In addition, a phytochemical study of TxAE led to the isolation of 2 previously described compounds: pebrellin and xanthomicrol. This is the first time that these compounds have been identified in a plant extract with hypolipidemic effect. The results suggest the possible therapeutic potential of TxAE as a hypolipidemic agent supporting the usage of T. angustifoliaas a traditional medicine. |
| Databáze: |
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