| Autor: |
do Socorro Silva Costa, Perpétua, Woycinck Kowalski, Thayne, Rosa Fraga, Lucas, Furtado Feira, Mariléa, Nazário, Ana Paula, MarceloAranha Camargo, Luis, Iop de Oliveira Caldoncelli, Daniele, Irismar da Silva Silveira, Maria, Hutz, Mara Helena, Schüler-Faccini, Lavínia, Sales Luiz Vianna, Fernanda |
| Zdroj: |
Pharmacogenomics; May 2019, Vol. 20 Issue: 7 p503-516, 14p |
| Abstrakt: |
Aim:To evaluate the effects of gene polymorphisms in the treatment of erythema nodosum leprosum with prednisone/thalidomide. Patients & methods:A total of 152 patients from different regions of Brazil were included. Generalized estimating equation was used to evaluate the influence of polymorphisms and haplotypes on the drug dose variation throughout the treatment. Results:An association between the genotype tuberculoid of polymorphism ABCB13435C>T (rs1045642; p = 0.02) and prednisone dose was found in the recessive model. An association between the haplotypes 1031T/-863C/-857C/-308A/-238G (p = 0.006) and 1031T/-863C/-857T/-308A/-238G (p = 0.040) of the TNFgene and theCYP2C19*2polymorphism were also identified, in relation to thalidomide dosage variation over the course of treatment. Conclusion:This work presents the first pharmacogenetic report of association between gene polymorphisms and erythema nodosum leprosum treatment with prednisone/thalidomide. |
| Databáze: |
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