| Autor: |
Rankin, Judith C., Ledford, Barry E., Jonsson, Haldor T., Baggett, Billy |
| Zdroj: |
Biology of Reproduction; March 1979, Vol. 20 Issue: 2 p399-404, 6p |
| Abstrakt: |
A uterine decidual cell reaction (DCR) was induced in hormone-primed ovariectomized mice by injection of 10 µl of sesame oil or by crushing 1 uterine horn with hemostats (trauma). Either stimulation led to a rapid elevation (within 15 min) of the cAMP level in the stimulated horn. Rapid proliferation of decidual cells began 30 h after stimulation. Oil stimulation also resulted in a 6-fold increase in cGMP levels in both the stimulated and unstimulated uterine horns within 15 min. Pretreatment with indomethacin blocked the oil-induced cyclic nucleotide increases and the subsequent DCR. Pretreatment with indomethacin did not, however, completely prevent the increase in cAMP and decidualization in the uterine horns stimulated by crushing.Prostaglandin F2α(PGF2α) levels were measured following oil and trauma stimulation of the DCR. With either treatment, there was a rapid (within 5 min) 10-fold increase in PGF2αlevels in the stimulated horn. Pretreatment with indomethacin abolished this increase. |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
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