| Autor: |
Hakala, Elina, Hanski, Leena L., Yrjönen, Teijo, Vuorela, Heikki J., Vuorela, Pia M. |
| Zdroj: |
Natural Product Communications; June 2015, Vol. 10 Issue: 6 |
| Abstrakt: |
The purpose of this study was to investigate the effect and selectivity of an extract of Schisandra chinensisberries against Chlamydia pneumoniaeand C. trachomatis. Among the ethnopharmacological uses of the extract from Schisandrae fructusare cough and pneumonia. Therefore we focused on respiratory pathogens. The extract completely inhibited the growth of C. pneumoniaestrain CV6 at 250 μg/mL concentration. The inhibition of C. pneumoniaeand C. trachomatisgrowth was dose dependent and established with three different strains. The extract inhibited C. pneumoniaeproduction of infectious progeny in a dose dependent manner. Chlamydia selectivity was elucidated with growth inhibition measurements of three other respiratory bacterial species. A pure compound found in Schisandra chinensisberries, schisandrin B at 20.0 μg/mL concentration inhibited the growth of both C. pneumoniaeand C. trachomatis. The extract was found to be non-toxic to the human host cells. These findings highlight the potential of the extract from Schisandra chinensisberries as a source for antichlamydial compounds. |
| Databáze: |
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