| Autor: |
Mathisen, Glenn, Shelub, Aaron, Truong, Jonathan, Wigen, Christine |
| Zdroj: |
Medicine; September 2010, Vol. 89 Issue: 5 p251-284, 34p |
| Abstrakt: |
Despite the advent of new antifungal agents, coccidioidal meningitis (CM) remains a difficult-to-treat condition with significant morbidity and mortality. In this study we directly compare the clinical presentation and management of patients with Coccidioides immitismeningitis in the azole era (after 1980) to that of a cohort of patients from the pre-azole era. We reviewed 30 CM cases seen at 3 Los Angeles hospitals between the years 1993 to 2008 ("2008 cohort") and compared them to 31 patients ("1980 cohort") described by Bouza et al in a previous study. The demographics and clinical presentation of patients in the 2008 cohort were similar to those of the 1980 cohort except for a higher incidence of Hispanic patients (2008 53% vs. 1980 6%) and a greater percentage of patients with underlying, predisposing clinical conditions (2008 66% vs. 1980 32%). Ten patients in the 2008 cohort had human immunodeficiency virus/acquired immunodeficiency syndrome (HIV/AIDS), a condition not reported in the earlier study. Laboratory findings were similar between the 2 groups except for a lower incidence of peripheral leukocytosis and eosinophilia in the 2008 group. |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
|
