THE TEMPORAL PROFILE OF CALCINEURIN INHIBITION BY CYCLOSPORINE IN VIVO1

Autor: Halloran, Philip F., Helms, Lisa M. H., Kung, Lina, Noujaim, Jean
Zdroj: Transplantation; November 1999, Vol. 68 Issue: 9 p1356-1361, 6p
Abstrakt: Cyclosporine (CsA) acts by inhibiting the phosphatase calcineurin (CN), but the time course and extent of inhibition in vivo are unknown. We examined the effect of single oral CsA doses on CN activity in humans and mice in vivo.
Databáze: Supplemental Index