A RAPID IMMUNOCYTOCHEMICAL ASSAY FOR CMV DETECTION IN PERIPHERAL BLOOD OF ORGANTRANSPLANTED PATIENTS IN CLINICAL PRACTICE

Autor: HALWACHS, G., ZACH, R., POGGLITSCH, H., HOLZER, H., TIRAN, A., IBERER, F., WASLER, A., TSCHELIESSNIGG, H. P., LANZER, G., FÖLSCH, B., WILDERS-TRUSCHNIG, M.
Zdroj: Transplantation; August 1993, Vol. 56 Issue: 2 p338-341, 4p
Abstrakt: This study describes clinical experience with a rapid method for diagnosis of cytomegalovirus infection in organ-transplanted patients, based on the detection of CMV-specific antigens in peripheral polymorphonuclear cells with a mixture of monoclonal antibodies. This CMV-pp65 assay was formerly called the “CMV immediate early antigen assay.” A group of 180 organ-transplanted patients were examined with this assay; 75 of them could be observed from the date of transplantation. These 75 patients consisted of two groups: 59 kidney transplant patients receiving no CMV hyperimmuno-globulin prophylaxis (group I), 13 heart-transplanted patients, and 3 liver transplanted patients receiving prophylaxis (group II). Group III consisted of 105 patients who had been transplanted ca. 2 years before starting this study.
Databáze: Supplemental Index