| Autor: |
OUWEHAND, ALICE J., BAAN, CARLA C., GROENEVELD, KEES, BALK, AGGIE H. M. M., JUTTE, NlCOLET H. P. M., BOS, EGBERT, CLAAS, FRANS H. J., WEIMAR, WlLLEM |
| Zdroj: |
Transplantation; January 1993, Vol. 55 Issue: 1 p154-158, 5p |
| Abstrakt: |
Graft-infiltrating lymphocytes from patients who were prophylactically treated with OKT3 or horse an-tilymphocyte globulin (H-ALG) were found to have different specificity patterns from those in the control group that received cyclosporine from the day of transplantation. This prophylactic treatment led to a significant decrease of the HLA-DR-directed cytotoxicity, while the cytolytic response against HLA-class I mismatches was hardly affected. In H-ALG patients without rejection, the percentages of class I-reactive cultures were found to be lower than in the other treatment groups, which was mainly due to a lower percentage of HLA-B-reactive cultures. In CsA and OKT3 patients, cytotoxic T cells were rather directed to HLA-B mismatches than to HLA-A antigens, while in H-ALG patients no difference in HLA-A and B-directed cytotoxicity was found. Our data suggest that OKT3 and H-ALG influence the specificity of the T cell allorepertoire, resulting in a decreased frequency of class II-specific cytotoxic T cells after transplantation. H-ALG also has a downregulating influence on the CTL response against HLA class I (HLA-B) antigens. In some patients a fast regeneration of these cells occurs, which results in a higher rejection incidence during the first posttrans-plant year. |
| Databáze: |
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