| Autor: |
Doughty, SW, Blaney, FE, Orlek, BS, Richards, WG |
| Zdroj: |
Protein Engineering Design and Selection; February 1998, Vol. 11 Issue: 2 p95-99, 5p |
| Abstrakt: |
A series of highly toxic snail venoms, the ω-conotoxins, have been shown to bind selectively, and often irreversibly to the N-type voltage-gated calcium channel α-1 subunit. The most potent of these is known as ω-conotoxin GVIA from the species Conus geograhus, a marine snail that has been responsible for a number of human fatalities. Using theoretical techniques we represent a plausible binding model of the conotoxin to a loop region of the channel. Our model of the toxin binding region also contains a possible EF-hand motif and we suggest that this Ca2+ binding domain lies on the ion permeation pathway, a possible CA2+ recruitment site.Key words: calcium channel/conotoxin/EF-hand/molecular model |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
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