Randomized comparative study of ampicillinsulbactam vsceftriaxone for treatment of soft tissue and skeletal infections in children

Autor: KULHANJIAN, JULIE, DUNPHY, MARY GAIL, HAMSTRA, SCOTT, LEVERNIER, KATHERINE, RANKIN, MICHAEL, PETRU, ANN, AZIMI, PARVIN
Zdroj: The Pediatric Infectious Disease Journal; September 1989, Vol. 8 Issue: 9 p605-610, 6p
Abstrakt: In a prospective study 105 children hospitalized with soft tissue infection, 11 children with suppurative arthritis and 9 children with osteomyelitis were treated with either parenterally administered ampicillin/sulbactam or ceftriaxone. Treatment was randomized using a computer-generated table in a 2:1 fashion: 84 patients received ampicillin/sulbactam and 41 patients received ceftriaxone. Organisms isolated from wound site or blood cultures included Staphylococcus aureus(33), Streptococcus pyogenes(19), Haemophilus influenzae(9) including 4 beta-lactamase-positive organisms, Streptococcus pneumoniae(5), Neisseria gonorrhoeae(3) and 9 other organisms. Clinical and bacteriologic response was satisfactory in 100±
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