| Autor: |
JOB, JAYAKARAN S., HALSEY, NEAL A., BOULOS, REGINALD, HOLT, ELIZABETH, FARRELL, DOROTHY, ALBRECHT, PAUL, BRUTUS, JEAN R., ADRIEN, MARIO, ANDRE, JEAN, CHAN, EDWARD, KISSINGER, PATRICIA, BOULOS, CARLO |
| Zdroj: |
The Pediatric Infectious Disease Journal; April 1991, Vol. 10 Issue: 4 p303-310, 8p |
| Abstrakt: |
A group of 2097 Haitian infants 6 to 11 months of age were randomized to receive Schwarz or Edmonston-Zagreb strain measles vaccines containing 10− to 500-fold more vaccine viral particles than standard potency vaccines. No unusual adverse reactions were noted. Edmonston-Zagreb vaccines were more effective than equivalent doses of Schwarz vaccines as measured by the proportion of vaccinated children with measles antibody concentrations ≥200 mIU/ml 2 months after vaccination and the persistence of antibody at 18 to 24 months of age. High titer Edmonston-Zagreb vaccine administered at 6 months of age induced antibody concentrations ≥200 mIU/ml in 83 of infants by plaque reduction neutralization and 93 of infants by enzyme-linked immunosor-bent assay with high rates of antibody persistence at 12 to 24 months of age. The World Health Organization recommends high titer Edmonston-Zagreb measles vaccines for routine use at 6 months of age in areas where measles is an important cause of mortality in young infants. |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
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