| Autor: |
Kuroda, Takai, Shiohara, Eiichi, Haba, Yoshiaki, Hanazaki, Kazuhiro, Homma, Tatsuji, Iwatsuki, Kazuhiko, Chiba, Shigetoshi |
| Zdroj: |
Pancreas; May 1994, Vol. 9 Issue: 3 p354-360, 7p |
| Abstrakt: |
Effects of prostaglandin (PG) El on ischemia-reperfusion (I-R) injury to the pancreas was evaluated using isolated in vivo perfused dog pancreas. Pancreatic endocrine and exocrine functions were stimulated with 10−12M cholecystokinin octapeptide (CCK-8). This amount of CCK-8 promoted production of insulin, glucagon, PGI2, and thromboxane (Tx) A2in the pancreas. Sixty minutes of ischemia and subsequent reperfusion induced damage to pancreatic ductular, acinar, and β cells. Intra-arterial administration of PGE, at a dose of 0.5 pg/kg/min throughout the experiment prevented the I-R injury, reducing plasma lipid peroxides, and elevating PGI, without changing TxA2in the pancreas. PGE2thus appears to protect pancreatic function from I-R injury both by depressing the effect of free-radicals and by decreasing TxA2PGI2which predicts cell injury. |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
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