Immunohistochemistry and Electron Microscopy for Diagnosis of Neuroendocrine Tumors

Autor: Yoshiyuki Osamura, R., Kumaki, Nobue, Kajiwara, Hiroshi, Sekido, Yasutomo, Yasuda, Masanori, Umemura, Shinobu
Zdroj: Pathology Case Reviews; September 2002, Vol. 7 Issue: 5 p193-200, 8p
Abstrakt: This review article describes various neuroendocrine (NE) markers used for the diagnosis of NE neoplasms. These NE markers include synaptophysin, chromogranin A, N-CAM, and SNARE proteins (SNAP −25). EM demonstration of secretory granules is also emphasized in the definitive diagnosis of NE tumors. Three representative cases are included in which immunohistochemistry and electron microscopy are applied in diagnostic workup.
Databáze: Supplemental Index