| Autor: |
Tekes K., Kornélia, Hantos M., Mónika, Gyenge M., Melinda, Bizderi B., Borbála, Kecskeméti V., Valéria |
| Zdroj: |
International Journal of Diabetes & Metabolism; March 2019, Vol. 13 Issue: 3 p147-153, 7p |
| Abstrakt: |
It is widely accepted that OFQ/N is involved in the metabolic neuropathic pain caused by diabetes mellitus. In our present study we aimed to determine whether long-term diabetes characterized by hyperglycaemia has any effect on endogenous OFQ/N levels. Diabetes was initiated in 8-week old male Wistar rats by intravenous administration of streptozotocin (60mg/kg body weight). Body weight and blood glucose levels were measured weekly and OrphaninFQ/nociceptin (OFQ/N) levels were determined by radioimmunoassay every two weeks between 2 to 16 weeks of the diabetic period. Neither plasma nor CSF OFQ/N levels showed significant difference from control in long-term diabetic rats. Age-dependence of both plasma and CSF OFQ/N levels reached the adult level in 3-month old rats. It is concluded that the metabolic neuropathic pain observed in streptozotocin-induced experimental diabetes is not related to changes in plasma or CSF levels of endogenous OFQ/N. (Int J Diabetes Metab 13: 147-153, 2005) |
| Databáze: |
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