| Autor: |
Kwan, Patrick, Poon, Wai Sang, Ng, Ho-Keung, Kang, David E., Wong, Virginia, Ng, Ping Wing, Lui, Colin H.T., Sin, Ngai Chuen, Wong, Ka S., Baum, Larry |
| Zdroj: |
Pharmacogenetics and Genomics; November 2008, Vol. 18 Issue: 11 p989-998, 10p |
| Abstrakt: |
Many antiepileptic drugs (AEDs) prevent seizures by blocking voltage-gated brain sodium channels. However, treatment is ineffective in 30 of epilepsy patients, which might, at least in part, result from polymorphisms of the sodium channel genes. We investigated the association of AED responsiveness with genetic polymorphisms and correlated any association with mRNA expression of the neuronal sodium channels. |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
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