| Autor: |
Iezzi, Giovanna, Piattelli, Adriano, Rubini, Corrado, Artese, Luciano, Goteri, Gaia, Perrotti, Vittoria, Carinci, Francesco |
| Zdroj: |
Journal of Craniofacial Surgery; November 2008, Vol. 19 Issue: 6 p1618-1621, 4p |
| Abstrakt: |
The aim of the present study was to compare the expression of transforming growth factor (TGF) 1 in ameloblastomas (AMs) with different risk of recurrence by immunohistochemistry. A total of 29 cases of AMs were evaluated. The tumors were divided into 2 groups group A (10 cases) composed of unicystic and peripheral AMs, associated with a low risk of recurrence, and group B (19 cases) composed of solid AMs, associated with a high risk of recurrence. Statistical evaluation showed significant differences between groups A and B lesions, with higher values of positivity for TGF-1 in stromal cells in group B tumors (P= 0.0308). No statistically significant differences of immunoreactivity were found in vessels and odontogenic epithelium between the 2 groups. The increased TGF-1 expression in tumors with a high risk of recurrence could be explained with the fact that although TGF- acts as a potent tumor suppressor in the early stages of tumor progression, later it seems to enhance the invasive phenotype of the tumor. |
| Databáze: |
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