Effects of a Highly Selective Acetylcholine-Activated KChannel Blocker on Experimental Atrial Fibrillation

Autor: Machida, Taiichi, Hashimoto, Norio, Kuwahara, Ippei, Ogino, Yasuhiro, Matsuura, Junji, Yamamoto, Wataru, Itano, Yasuhiro, Zamma, Akira, Matsumoto, Ryo, Kamon, Junji, Kobayashi, Tsunefumi, Ishiwata, Norihisa, Yamashita, Toru, Ogura, Takehiko, Nakaya, Haruaki
Zdroj: Circulation: Arrhythmia and Electrophysiology; February 2011, Vol. 4 Issue: 1 p94-102, 9p
Abstrakt: The acetylcholine-activated Kcurrent (IK,ACh) is a novel candidate for atrial-specific antiarrhythmic therapy. The present study investigates the involvement of IK,AChin atrial fibrillation (AF) using NTC-801, a novel potent and selective IK,AChblocker.
Databáze: Supplemental Index