| Autor: |
Garden, G A, Moss, G B, Emonyi, W, Bwayo, J, Velentgas, P, Kreiss, J |
| Zdroj: |
International Journal of STD & AIDS; January 1993, Vol. 4 Issue: 1 p49-51, 3p |
| Abstrakt: |
Serum beta-2 microglobulin (β2-M) has prognostic value similar to lymphocyte profiles for predicting disease progression in those infected with the human immunodeficiency virus (HIV). However, the relationship between β2-M and HIV disease progression among inhabitants of countries with endemic tropical diseases has not been evaluated. To determine the relationship between serum β2-M levels and HIV infection and disease status in an African population, serum β2-M levels were measured in 369 patients attending a sexually transmitted disease (STD) clinic in Nairobi, Kenya. Mean serum β2-M was significantly higher in HIV seropositive than in HIV seronegative individuals. Among HIV infected patients, higher mean β2-M levels were observed in those with HIV associated symptoms or laboratory markers of advanced HIV disease. Significant inverse correlations between β2-M and the percentage of CD4 lymphocytes or CD4/CD8 ratio were found. These findings suggest that β2-M measurements may have prognostic value for HIV infected populations in developing countries. |
| Databáze: |
Supplemental Index |
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