| Autor: |
Thorngren, Margareta, Shafi, Shahida, Born, G.V.R. |
| Zdroj: |
The Lancet; May 1983, Vol. 321 Issue: 8333 p1075-1078, 4p |
| Abstrakt: |
The 'Simplate' technique for measuring skin bleeding time was adapted to quantify thromboxane A2in the emerging blood as the stable degradation product thromboxane B2in twelve Swedish and ten English volunteers. During the bleeding time thromboxane B2concentrations increased, but as the rate of blood loss fell the rate of production of thromboxane A2was constant. The English subjects had shorter bleeding times and produced more thromboxane A2than the Swedish subjects. When the Swedish subjects were grouped according to bleeding times those with the shortest had more thromboxane A2than those with longer bleeding times. Clotting venous blood in vitro produced much more thromboxane A2than bleeding-time blood and there was no correlation with bleeding time. Determination of the capacity of clotting blood to form thromboxane A2is therefore irrelevant to in-vivo haemostasis. Acetylsalicylic acid greatly diminished the appearance of thromboxane A2in the bleeding time and prevented the increase of thromboxane A2concentration with time. |
| Databáze: |
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| Externí odkaz: |
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