| Abstrakt: |
Objective: The Pro12Ala polymorphism in exon B of peroxisome proliferator‐activated receptor γ 2 (PPARγ2) gene has been related to obesity, insulin resistance, and risk of type 2 diabetes. In this study, the effect of the Pro12Ala polymorphism on long‐term changes in weight and body composition was investigated. Research Methods and Procedures: The Pro12Ala polymorphism was genotyped in 311 subjects who participated in our previous population‐based study. In that study, weight at birth, 7 years, 20 years, and 41 years, and ponderal index at birth and BMI and waist circumference at 41 years were recorded. Results: The Ala12allele of the PPARγ2gene was associated with high ponderal index at birth (2.77 ± 0.27 kg/m3in subjects with the Ala12Ala genotype, 2.79 ± 0.29 kg/m3in subjects with the Pro12Ala genotype, and 2.63 ± 0.25 kg/m3in subjects with the Pro12Pro genotype, p= 0.007, adjusted for gender) and weight at 7 years (p= 0.045) and tended to be associated with high birth weight (p= 0.094). Subjects with this allele gained less weight between 7 and 20 years (p= 0.043) and more weight between 20 and 41 years (p= 0.001) and ended up having higher waist circumference (p= 0.040) in adulthood than did subjects with the Pro12Pro genotype. Discussion: We conclude that the Pro12Ala polymorphism of the PPARγ2gene regulates weight and body composition from utero to adulthood. |
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