Hepatic metabolism of vitamin D3in streptozotocin-induced diabetic rat

Autor: Sulimovici, Sorel, Roginsky, Martin S.
Zdroj: European Journal of Endocrinology; March 1980, Vol. 93 Issue: 3 p346-350, 5p
Abstrakt: The effect of streptozotocin-induced diabetes on the in vitro conversion of vitamin D3to 25-hydroxyvitamin D3(25-OHD3) by isolated liver microsomes from rachitic rats was examined. Enzymic activity was significantly less than that observed in control animals (P< 0.001). Administration of insulin restored activity almost to control values. These findings provide evidence that diabetes in this animal model produces alterations in the metabolism of vitamin D.
Databáze: Supplemental Index