| Autor: |
Robertson, Brian, Owen, David, Stow, John, Butler, Carolynn, Newland, Claire |
| Zdroj: |
FEBS Letters; March 1996, Vol. 383 Issue: 1-2 p26-30, 5p |
| Abstrakt: |
We have examined the effects of two DTX homologues, toxin I and toxin K, on Kv1.1, Kv1.2 and Kv1.6 channels expressed in Xenopusoocytes. Toxin I blocked all three channels; in contrast, toxin K was selective for Kv1.1. Both toxins slowed channel activation and inactivation kinetics with 10 nM toxin I approximately doubling activation and inactivation time constants of Kv1.1. For the first time, we have demonstrated the selectivity of a DTX homologue for a single cloned Kv1 channel and suggest that these toxins may sterically hinder the conformational changes that occur during channel gating. |
| Databáze: |
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