| Autor: |
Roberts, David M., Pronobis, Mira I., Poulton, John S., Waldmann, Jon D., Stephenson, Elise M., Hanna, Shahnaz, Peifer, Mark |
| Zdroj: |
Molecular Biology of the Cell; June 2011, Vol. 22 Issue: 11 p1845-1863, 19p |
| Abstrakt: |
APC is a key tumor suppressor and Wnt signaling regulator, but its mechanism of action remains mysterious. We combined parallel assays in Drosophilaand cultured human colon cancer cell lines to test hypotheses regarding APC function and to develop novel hypotheses, using mutants altering its structure in specific ways. |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
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