Dabigatran in patients with myocardial injury after non-cardiac surgery (MANAGE): an international, randomised, placebo-controlled trial

Autor: Devereaux, P J, Duceppe, Emmanuelle, Guyatt, Gordon, Tandon, Vikas, Rodseth, Reitze, Biccard, Bruce M, Xavier, Denis, Szczeklik, Wojciech, Meyhoff, Christian S, Vincent, Jessica, Franzosi, Maria Grazia, Srinathan, Sadeesh K, Erb, Jason, Magloire, Patrick, Neary, John, Rao, Mangala, Rahate, Prashant V, Chaudhry, Navneet K, Mayosi, Bongani, de Nadal, Miriam, Iglesias, Pilar Paniagua, Berwanger, Otavio, Villar, Juan Carlos, Botto, Fernando, Eikelboom, John W, Sessler, Daniel I, Kearon, Clive, Pettit, Shirley, Sharma, Mukul, Connolly, Stuart J, Bangdiwala, Shrikant I, Rao-Melacini, Purnima, Hoeft, Andreas, Yusuf, Salim, Devereaux, P.J., Duceppe, Emmanuelle, Bangdiwala, Shrikant I., Connolly, Stuart, Eikelboom, John, Guyatt, Gordon, Kearon, Clive, Pettit, Shirley, Pogue, Janice, Rodseth, Reitze, Sessler, Daniel I., Vincent, Jessica, Yusuf, Salim, Vincent, Jessica, Di Diodato, Sara, Gasic, Zora, Mastrangelo, Louise J., Molnar, Sarah H., Pettit, Shirley, Swanson, Jennifer L., Tosh, Makayla L., Wells, Jennifer R., Botto, Fernando, Diaz, Rafael, Chow, Clara K., Berwanger, Otavio, Gonzales, Beatriz, Devereaux, P.J., Tandon, Vikas, Villar, Juan Carlos, Vásquez, Skarlet, Jansky, Petr, Dušek, Radovan, Meyhoff, Christian S., Coriat, Pierre, Hoeft, Andreas, Wittmann, Maria, Yonga, Gerald, Xavier, Denis, Rao, Mangala, Mathur, Nandini, Franzosi, Maria Grazia, Seletti, Elena, Malaga, German, Tumanan-Mendoza, Bernadette A., Tagle, Maria Pamela A., Szczeklik, Wojciech, Biccard, Bruce M., Alonso-Coello, Pablo, Popova, Ekaterine, Shields, Martin, Sessler, Daniel I., Devereaux, P.J., Biccard, Bruce M., Connolly, Stuart, Duceppe, Emmanuelle, Eikelboom, John, Guyatt, Gordon, Hoeft, Andreas, Jansky, Petr, Kearon, Clive, Le Manach, Yannick, Moayyedi, Paul, Pettit, Shirley, Pogue, Janice, Rodseth, Reitze, Sessler, Daniel I., van Zanten, Sander, Villar, Juan Carlos, Vincent, Jessica, Yusuf, Salim, Devereaux, P.J., Alonso-Coello, Pablo, Berwanger, Otavio, Biccard, Bruce M., Botto, Fernando, Chow, Clara K., Connolly, Stuart, Coriat, Pierre, Diaz, Rafael, Duceppe, Emmanuelle, Eikelboom, John, Fleischmann, Edith, Franzosi, Maria Grazia, Garg, Amit, Guyatt, Gordon, Hoeft, Andreas, Jansky, Petr, Karaye, Kamilu, Kearon, Clive, Le Manach, Yannick, Malaga, German, McFalls, Edward, Meyhoff, Christian S., Moayyedi, Paul, Pettit, Shirley, Pogue, Janice, Rodseth, Reitze, Sessler, Daniel I., Sigamani, Alben, Shields, Martin, Szczeklik, Wojciech, Tumanan-Mendoza, Bernadette A., van Zanten, Sander, Villar, Juan Carlos, Vincent, Jessica, Xavier, Denis, Yonga, Gerald, Yusuf, Salim, Connolly, Stuart, Belley-Côté, Emilie, Biedroń, Grzegorz, Borges, Flavia, Frosi Stella, Steffan, Haarmark Nielsen, Christian, Leong, Darryl P., Meyhoff, Christian S., Spence, Jessica, Tran, Allen, Wawrzycka-Adamczyk, Katarzyna, Yang, Stephen S., Yung, Terence, Wyse, D. George, Cheng, Davy, Johnstone, David E., Wells, George A., Joseph, Philip, Patel, Ameen, Leong, Darryl P., Gregus, Krysten, Lawrence, Kelly, Doharris, Lindsay, Conen, David, Cheung, Jason, Douketis, Jim, Wright, Douglas, Wikkerink, Spencer, Dechert, William, Panju, Mohamed, Azzam, Khalid, Rapanos, Theodore, Van Helder, Tomas, Shroff, Anjali, Hare, Jacqueline, Kidane, Biniam, Nguyen, Thang, Leydier, Larissa, Bayaraa, Vanessa, Parlow, Joel, DuMerton, Deborah A., Thakrar, Amar, Shelley, Jessica, Deligne, Benoit, Carling, Roberta Daila, Mrkobrada, Marko, Dresser, George K., Jacka, Michael J., Garg, Amit, Hornstein, David, Winkelaar, Gerrit B., Haider, Zoeb Hussain, Lanjewar, Pravina Prashant, Varughese, Valsamma, Calton, Rajneesh, Ahuja, Hemani, George, Preetha, Sharma, Ambika, Bhatt, Keyur Sureshchandra, Mangukiya, Dhaval Odhavajibhai, Nandaniya, Karshan Vira, Parekh, Viral Vasantrai, Pillai, Ashok Bhaskaran, Menon, Vidya P., Desai, Sanjay Channappa, Sidhu, Ravinder Singh, Gupta, Sandeep Kumar, George, Robbie K., Gurunath, T.R., Drummond, Leanne W., Torborg, Alexandra M., Küsel, Belinda S., Naidoo, Prebashini, Naidoo, Datshana P., Rajah, Chantal, Farina, Zane, von Rahden, Richard Peter, Gumede, Simphiwe, Chishala, Chishala, Coetzee, Ettienne, Dyer, Robert A., Diedericks, Johan, Bielański, Piotr, Kaczmarek, Bogusz, Studzińska, Dorota, Zaniewski, Maciej, Libura, Marek Józef, Zacharias-Nalichowski, Tomasz Mikołaj, Sega, Aurelia A.S., Salwa, Jakub, Kózka, Mateusz, Górka, Jacek, Wludarczyk, Anna, Nowak-Kózka, Ilona, Grudzień, Paweł Szczepan, Gucwa, Jaroslaw W., Słowiaczek, Michał Piotr, Dobosz, Paweł P.D., Gögenur, Ismail, Eriksen, Jens Ravn, Borup, Tine, Kirkegaard, Tove, Isbye, Dan, Sonne, Asger, Rasmussen, Lars S., Pedersen, Sofie, Troensegaard, Hannibal, Duus, Camilla L., Halle, Benedikte M., Gundel, Ossian N., Bernholm, Katrine F., Martinsen, Kristian Rønsholt, Pedersen, Søren, Itenov, Theis S., Camio, Elena, Vázquez, Carles, Matarin, Silvia, Cano, Esther, Álvarez-García, Jesús, India, Inmaculada, González-Osuna, Aránzazu, Vives, Marc, Rosselló, Elena, Serrano, Ana B., Turiel, Maurizio, Drago, Lorenzo, Colombo, Chiara, Marra, Federica, Mos, Lucio, Arteni, Franco, Lembo, Rosalba, Ortalda, Alessandro, Passarani, Simonetta, Mokini, Zhirajr, Figueiredo, Estevao Lanna, Werner, Gustavo Fonseca, Petriz, Joao Luiz, Maia, Lilia Nigro, Bergo, Ricardo R., Precoma, Dalton Bertolim, Saraiva, José Francisco Kerr, Vilamajo, Oscar Gomez, Allegrini, Eduardo, Benzadón, Mariano, Parody, Maria Leonor, Duronto, Ernesto A., Ingaramo, Adrián C., Parra, Gustavo Adolfo, Novoa, Danny, Miller, Scott A., Thomas, Sabu, Karlapudi, Sudhakar P., Bourji, Mohamad H., Banerjee, Subhash, Gupta, Anita, Opole, Isaac O., Fischer, Michal, Jansky, Petr, Mendoza, Victor Lecaros, Reyes, Eugenio Borja, Pierson, Richard J., Shields, Martin O., Chow, Clara K., Coriat, Pierre, Piriou, Vincent, Wittmann, Maria, Zacharowski, Kai, Yonga, Gerald, Rotta-Rotta, Aida, Paper, Main, Devereaux, P.J., Duceppe, Emmanuelle, Guyatt, Gordon, Tandon, Vikas, Rodseth, Reitze, Biccard, Bruce M., Xavier, Denis, Szczeklik, Wojciech, Meyhoff, Christian S., Vincent, Jessica, Franzosi, Maria Grazia, Srinathan, Sadeesh K., Erb, Jason, Magloire, Patrick, Neary, John, Rao, Mangala, Rahate, Prashant, Chaudhry, Navneet, Mayosi, Bogani, de Nadal, Miriam, Paniagua Iglesias, Pilar, Berwanger, Otavio, Villar, Juan Carlos, Botto, Fernando, Eikelboom, John, Sessler, Daniel I., Kearon, Clive, Pettit, Shirley, Sharma, Mike, Connolly, Stuart, Bangdiwala, Shrikant I., Rao-Melacini, Purnima, Hoeft, Andreas, Yusuf, Salim
Zdroj: The Lancet; June 2018, Vol. 391 Issue: 10137 p2325-2334, 10p
Abstrakt: Myocardial injury after non-cardiac surgery (MINS) increases the risk of cardiovascular events and deaths, which anticoagulation therapy could prevent. Dabigatran prevents perioperative venous thromboembolism, but whether this drug can prevent a broader range of vascular complications in patients with MINS is unknown. The MANAGE trial assessed the potential of dabigatran to prevent major vascular complications among such patients.
Databáze: Supplemental Index