Studies towards the synthesis of the marine metabolite, octalactin A

Autor: Hulme, Alison N., Howells, Garnet E.
Zdroj: Tetrahedron Letters; January 1997, Vol. 38 Issue: 47 p8245-8248, 4p
Abstrakt: Studies towards the synthesis of the marine metabolite octalactin A 1, are described. Key steps in this strategy include an antialdol reaction to set the C 7C 8stereochemistry, Horner Wadsworth Emmons coupling to give the trisubstituted E-double bond and a novel samarium-mediated cyclisation reaction.
Databáze: Supplemental Index