| Autor: |
Hulme, Christopher, Peng, John, Morton, George, Salvino, Joseph M., Herpin, Tim, Labaudiniere, Richard |
| Zdroj: |
Tetrahedron Letters; January 1998, Vol. 39 Issue: 40 p7227-7230, 4p |
| Abstrakt: |
This communication reveals the synthesis and application of a novel resin bound isonitrile. The resin is an example of a novel safety-catch linker which upon BOC-activation can be resin cleaved with a variety of nucleophiles. Use of this polymer supported isonitrile in the Ugi multi-component reaction (MCR), followed by resin clipping and cyclization allows access to diverse arrays of 1,4-benzodiazepine-2,5-diones, diketopiperazines and ketopiperazines respectively. The methoxide safety-catch clipping strategy and subsequent solution phase cyclization offers similar advantages to a traceless linker. |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
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