| Autor: |
Indovina, A., Liberti, G., Majolino, I., Buscemi, F., Scimè, R., Gentile, S., Vasta, S., Pampinella, M., Cappuzzo, V., Santoro, A. |
| Zdroj: |
International Journal of Artificial Organs; May 1993, Vol. 16 Issue: Supplement 5 p30-34, 5p |
| Abstrakt: |
We report the preliminary results of a study exploring the possibility of collecting circulating progenitor cells (PBSC) with a protocol based on the administration of single doses (4 g/m2) of cyclophosphamide and G-CSF (5 or 10- μg/kg) in 9 patients with non Hodgkin's lymphoma. The peak level of CD34+ cells occurred after a median of 10 days (range 8-11), generally coinciding with the median peak level of CFU-GM, with a mean 31.27 fold increase above basal levels. 3 (range 2-5) leukaphereses were required to harvest a median number of 25. 1x104/kg (8-105) CFU-GM and of 9.4x106/kg (1.2-25) CD34+cells. No difference was recorded between 5 and 10 μg/kg of G-CSF in terms of PBSC yield. In transplanted patients, a strong correlation was found between CD34+ cells infused/kg and platelet recovery (r= -0.8, p=0.002). No toxicity was observed and apheretic procedures were regularly performed outpatiently. Our conclusion is that this protocol is particularly suitable for an outpatient treatment/collection program. |
| Databáze: |
Supplemental Index |
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