| Autor: |
Nordström, Viola, Herzer, Silke |
| Zdroj: |
Neuroforum; November 2017, Vol. 23 Issue: 4 pA157-A166, 10p |
| Abstrakt: |
Alzheimer’s disease is a degenerative disease of the central nervous system, which leads to severe deficits in memory and orientation by a progressive loss of neurons and synapses. Soluble β-amyloid oligomers are highly neurotoxic precursors of β-amyloid fibrils that accumulate in Alzheimer’s disease. Binding of β-amyloid oligomers to synaptic insulin receptors leads to neuronal insulin resistance, which significantly contributes to cognitive impairments. |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
|
