| Autor: |
Marano, Lidia, Bestetti, Alberto, Lomuscio, Alberto, Tagliabue, Luca, Castinl, Diego, Tarricone, Diego, Dario, Paola, Tarolo, Gian Luigi, Fiorentini, Cesare |
| Zdroj: |
Acta cardiologica; February 2000, Vol. 55 Issue: 1 p9-15, 7p |
| Abstrakt: |
We studied the effects of glucose, insulin, and KCI infusion (GIK), on regional myocardial perfusion and function by 99m-Tc-tetrofosmin-gated SPECT.Methods- we studied 21 male patients with their first uncomplicated acute myocardial infarction (AMI). All patients underwent a rest and submaximal stress perfusion study before and after 24-hour infusion of GIK-solution (group A) or saline solution (group B).Results- Group A showed better stress tolerance and ischaemic threshold improvement after GIK infusion whilst no statistical differences were found between basal and post-infusion test in group B.At first the stress test in group A, of the 192 segments analysed, 52 (27%) showed reversible perfusion defect. In group B, of 144 segments analysed, 31 (21%) showed reversible perfusion defect. A postinfusion analysis in group A showed a post-GIK end-diastolic significant count improvement in 21 segments, and a post-GIK end-systolic count improvement in 22 segments. In group B, perfusion increase was observed only in 4 segments, whilst systolic thickening increase was observed only in I segment.Conclusion- these data demonstrate the efficacy of GIK infusion to improve regional myocardial perfusion and function mainly in segments adjacent to the recently infarcted area. |
| Databáze: |
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