Adjunctive Chemotherapy of Infection-Induced Staghorn Calculi

Autor: Griffith, Donald P., Moskowitz, P.A., Carlton, C. Eugene
Zdroj: The Journal of Urology; June 1979, Vol. 121 Issue: 6 p711-715, 5p
Abstrakt: Bacteria induce urinary crystallization of struvite and carbonate-apatite as a by-product of ureolysis by urease. Eradication of infection and/or inhibition of urease with acetohydroxamic acid for 5 to 30 months retarded stone growth and brought about partial or complete dissolution of stones in 9 patients. Long-term chemotherapy with antimicrobial agents that achieve sterile urine or acetohydroxamic acid in those patients with recalcitrant infection lessens the risk of recurrent calculogenesis.
Databáze: Supplemental Index