| Autor: |
Fotio, A.L., Olleros, M.L., Vesin, D., Tauzin, S., Bisig, R., Dimo, T., Nguelefack, T.B., Dongo, E., Kamtchouing, P., Garcia, I. |
| Zdroj: |
International Journal of Immunopathology and Pharmacology; January 2010, Vol. 23 Issue: 1 p61-72, 12p |
| Abstrakt: |
Sclerocarya birreais a medicinal plant used for the treatment of inflammatory- and bacterial-related diseases. The present study investigated in vitroand in vivothe effects of the stem bark methanol extract of S. birrea. Nitrite, TNF, IL-1β, IL-6 and IL-12p40 production by bone marrow-derived macrophages (BMDM) pre-incubated with or without S. birrea, and stimulated with Lipopolysaccharide (LPS) or infected with live Mycobacterium bovisBacillus Calmette Guérin (BCG) was evaluated. S. birreaextract inhibited, in a concentration-dependent manner, nitrite, TNF, IL-1β, IL-6 and IL-12p40 production by BMDM stimulated with LPS or infected with live BCG. The iNOS expression was reduced by S. birreaafter stimulation of BMDM with LPS. In addition, S. birreainhibited the nuclear factor κB (NF-κB) activation by both LPS and BCG. The effects of the plant extract were also evaluated in an in vivomodel of liver injury induced by D-galactosamine/LPS (D-GalN/LPS) administration in mice. S. birrealimited D-GalN/LPS-liver injury as assessed by a reduction in transaminases and TNF, IL-1β, IL-6 serum levels, and translocation of NF-κB to the nucleus. Taken together, our data indicate that stem bark methanol extract of S. birreapossesses anti-inflammatory properties by inhibiting NF-κB activation and cytokine release induced by inflammatory or infectious stimuli. |
| Databáze: |
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