Cultures of the Marine Bacterium Pseudovibrio denitrificansAb134 Produce Bromotyrosine-Derived Alkaloids Previously Only Isolated from Marine Sponges

Autor: Nicacio, Karen J., Ióca, Laura P., Fróes, Adriana M., Leomil, Luciana, Appolinario, Luciana R., Thompson, Christiane C., Thompson, Fabiano L., Ferreira, Antonio G., Williams, David E., Andersen, Raymond J., Eustaquio, Alessandra S., Berlinck, Roberto G. S.
Zdroj: Journal of Natural Products; February 2017, Vol. 80 Issue: 2 p235-240, 6p
Abstrakt: Herein we report the isolation and spectroscopic identification of fistularin-3 (1), 11-hydroxyaerothionin (2), and verongidoic acid (3), as well as the UPLC-HRMS detection of aerothionin (4), homopurpuroceratic acid B (5), purealidin L (6), and aplysinamisine II (7), from cultures of the marine bacterium Pseudovibrio denitrificansAb134, isolated from tissues of the marine sponge Arenosclera brasiliensis. These results unambiguously demonstrate for the first time that bromotyrosine-derived alkaloids that were previously isolated only from Verongidasponges can be biosynthesized by a marine bacterium.
Databáze: Supplemental Index